Colozo 145 mcg Capsules contain Linaclotide, a guanylate cyclase-C (GC-C) agonist used for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C). It helps improve bowel movement frequency, stool consistency, and reduces abdominal pain by increasing intestinal fluid secretion and accelerating gut transit.
Uses / Indications
Colozo 145 mcg is indicated for:
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Chronic Idiopathic Constipation (CIC)
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Irritable Bowel Syndrome with Constipation (IBS-C) in adults
Mechanism of Action
Linaclotide works by activating guanylate cyclase-C receptors on the intestinal epithelium. This leads to:
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Increased cyclic GMP (cGMP) levels
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Enhanced secretion of chloride and bicarbonate into the intestinal lumen
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Increased intestinal fluid and faster bowel movement
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Reduced visceral pain signaling
Dosage & Administration
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Recommended Dose: 145 mcg once daily
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Should be taken on an empty stomach, at least 30 minutes before the first meal of the day
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Capsule should be swallowed whole with water
⚠️ Dosage should be taken strictly as prescribed by a physician.
Side Effects
Common side effects include:
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Diarrhea
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Abdominal pain
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Flatulence
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Abdominal distension
Less common but serious:
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Severe diarrhea leading to dehydration
Precautions & Warnings
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Not recommended for patients below 18 years
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Contraindicated in known or suspected mechanical gastrointestinal obstruction
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Use caution in patients with severe diarrhea
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Discontinue if severe diarrhea occurs
Drug Interactions
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No major systemic drug interactions reported due to minimal absorption
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Inform doctor about all ongoing medications
Storage Instructions
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Store below 25°C
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Keep away from moisture and heat
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Keep out of reach of children
Key Highlights
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Effective treatment for IBS-C and chronic constipation
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Improves bowel regularity and abdominal discomfort
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Once-daily oral dosing
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Minimal systemic absorption
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Trusted brand from Dr. Reddy’s Laboratories
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