Cenforce 100 (Sildenafil 100 mg) (Per Box)

Cenforce 100 mg contains 100 mg of Sildenafil Citrate, a potent phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED) in men. It helps improve the ability to achieve and maintain a firm erection during sexual activity by enhancing blood flow to the penis when sexual stimulation is present.

Approved Indications

• Erectile dysfunction (ED) in adult males

• May be prescribed for men with ED caused by diabetes, stress, cardiovascular issues, or age-related decline

Mechanism of Action

Sildenafil works by selectively inhibiting the PDE5 enzyme, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) — a key molecule involved in relaxing smooth muscle in the corpus cavernosum of the penis. This relaxation allows for increased blood flow, leading to erection during sexual stimulation.

Clinical Benefits

• Fast onset of action: typically within 30 to 60 minutes

• Duration of effectiveness: up to 4 to 6 hours

• Helps restore confidence, improve sexual performance, and enhance relationship satisfaction

• Higher strength formulation for men who do not respond adequately to lower doses (e.g., 50 mg)

Dosage Guidance

• Standard recommended dose: 100 mg, taken once daily as needed

• Should be taken approximately 1 hour before sexual activity

• Sexual stimulation is required for effectiveness

• Do not take more than one tablet in 24 hours

• Dose adjustments may be required based on tolerance and effectiveness

Drug Interactions

• Contraindicated with nitrates (e.g., nitroglycerin) due to risk of dangerous hypotension

• Avoid concurrent use with other PDE5 inhibitors

• Caution with CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin)

• May interact with alpha-blockers, blood pressure medications, and alcohol

Food Interactions

• High-fat meals may delay absorption and reduce onset of action

• Best taken on an empty stomach or with a light meal

• Avoid grapefruit juice, which can alter drug metabolism

• Limit or avoid alcohol, which may reduce effectiveness or increase side effects

Precautions

• Not suitable for use in men with certain cardiac conditions, severe hypotension, or recent stroke/heart attack

• Use with caution in patients with liver or kidney impairment

• Not intended for women or children under 18

• Avoid use if advised to refrain from sexual activity for medical reasons

• May cause temporary side effects such as headache, facial flushing, nasal congestion, dizziness, or visual changes