Jakavi 20 mg (Ruxolitinib) is a targeted oral therapy that selectively inhibits JAK1 and JAK2 enzymes, key regulators of cytokine signaling and blood cell production. This pharmaceutical-grade tablet helps manage myeloproliferative disorders, blood cancers, and post-transplant immune complications by reducing overactive inflammatory signaling.

Uses of Jakavi 20 mg

Approved Uses

• Treatment of intermediate or high-risk myelofibrosis

• Management of polycythemia vera in patients intolerant or resistant to hydroxyurea

• Reduction of splenomegaly and disease-related symptoms

• Management of post-transplant immune complications

Off-Label / Investigational Uses

• Certain inflammatory or autoimmune conditions under physician guidance

• Research-based use in hematologic disorders

Mechanism of Action

Jakavi 20 mg works by inhibiting JAK1 and JAK2, enzymes that mediate cytokine signaling and hematopoiesis. By modulating these pathways, Ruxolitinib helps normalize blood cell production, reduce inflammation, and control abnormal immune responses.

Dosage & Administration

• Typical adult dose: 20 mg orally twice daily, or as prescribed by a physician

• Can be taken with or without food

• Dose adjustments may be required based on liver or kidney function and treatment response

Common Side Effects

• Headache or dizziness

• Fatigue

• Mild nausea or diarrhea

• Low blood counts (anemia, thrombocytopenia, neutropenia)

Serious Side Effects

• Severe infections due to immune suppression

• Liver enzyme abnormalities

• Rare allergic reactions

• Blood clotting disorders

Drug Interactions

• CYP3A4 inhibitors or inducers may affect Ruxolitinib levels

• Monitor when used with immunosuppressants or other hematologic therapies

• Consult a physician for all concurrent medications

Food & Lifestyle Interactions

• Can be taken with or without meals

• Avoid live vaccines due to immune suppression

• Maintain regular monitoring of blood counts and liver function

Monitoring & Tests

• Complete blood counts regularly

• Liver and kidney function tests

• Monitor for infections and adverse effects

Precautions & Warnings

• Use only under physician supervision

• Not recommended during pregnancy or breastfeeding without guidance

• Caution in patients with liver or kidney impairment

• Avoid abrupt discontinuation without medical advice