Jakavi 15 mg (Ruxolitinib 15mg) (Per Box)

Jakavi 15 mg (Ruxolitinib) is a targeted oral therapy for managing myeloproliferative disorders and immune-related conditions. As a Janus Kinase (JAK) inhibitor, it regulates abnormal signaling pathways in blood cell production, reducing symptoms and disease progression.

This pharmaceutical-grade tablet ensures precise dosing under physician supervision.

Uses of Jakavi 15 mg

Approved Uses

• Treatment of intermediate or high-risk myelofibrosis

• Management of polycythemia vera in patients intolerant or resistant to hydroxyurea

• Reduction of splenomegaly and disease-related symptoms

Off-Label / Investigational Uses

• Certain inflammatory or autoimmune disorders under physician guidance

• Research-based use in hematologic conditions

Mechanism of Action

Jakavi 15 mg inhibits JAK1 and JAK2 enzymes, key regulators of blood cell production and immune response. By modulating these pathways, it helps normalize abnormal cell growth and reduce inflammation in affected tissues.

Dosage & Administration

• Typical adult dose: 15 mg orally twice daily, or as prescribed

• Can be taken with or without food

• Dose adjustments may be necessary based on liver or kidney function and response to therapy

Common Side Effects

• Headache or dizziness

• Fatigue

• Mild nausea or diarrhea

• Anemia or low blood counts

Serious Side Effects

• Severe infections due to immune suppression

• Low blood counts (thrombocytopenia, neutropenia, anemia)

• Liver enzyme abnormalities

• Rare allergic reactions

Drug Interactions

• CYP3A4 inhibitors or inducers may alter Ruxolitinib levels

• Monitor when used with immunosuppressants or hematologic therapies

• Consult a physician for all concurrent medications

Food & Lifestyle Interactions

• Can be taken with or without meals

• Avoid live vaccines during therapy due to immune suppression

• Maintain regular monitoring of blood counts and liver function

Monitoring & Tests

• Complete blood counts regularly

• Liver and kidney function tests

• Monitor for infections and other adverse effects

Precautions & Warnings

• Use only under physician supervision

• Not recommended during pregnancy or breastfeeding without guidance

• Caution in patients with liver or kidney impairment