Jakavi 10 mg (Ruxolitinib) is a targeted oral therapy used to treat conditions related to abnormal blood cell production and immune system dysregulation. It is a Janus Kinase (JAK) inhibitor, which helps regulate signaling pathways involved in myeloproliferative disorders.

This pharmaceutical-grade tablet is designed for precision dosing under physician supervision.

Uses of Jakavi 10 mg

Approved Uses

• Treatment of intermediate or high-risk myelofibrosis

• Management of polycythemia vera in patients resistant or intolerant to hydroxyurea

• Reducing splenomegaly and disease-related symptoms

Off-Label / Investigational Uses

• Certain inflammatory or autoimmune conditions under research protocols

• Physician-supervised use in hematologic disorders

Mechanism of Action

Jakavi works by inhibiting Janus Kinase (JAK1 and JAK2) enzymes, which play a key role in the signaling pathways of blood cell production and immune regulation. By modulating these pathways, Ruxolitinib helps reduce abnormal cell growth and inflammation.

Dosage & Administration

• Typical adult dose: 10 mg orally twice daily, or as prescribed by a physician

• Can be taken with or without food

• Dose adjustments may be needed based on kidney or liver function and response to therapy

Common Side Effects

• Headache or dizziness

• Fatigue

• Mild nausea or diarrhea

• Anemia or reduced blood counts

Serious Side Effects

• Severe infections due to immune suppression

• Low blood counts (thrombocytopenia, neutropenia, anemia)

• Liver enzyme abnormalities

• Rare allergic reactions

Drug Interactions

• Strong CYP3A4 inhibitors or inducers may affect Ruxolitinib levels

• Monitor if taken with immunosuppressants or other hematologic therapies

• Consult physician for all concurrent medications

Food & Lifestyle Interactions

• Can be taken with or without meals

• Avoid live vaccines during therapy due to immune suppression

• Maintain regular physician follow-up for blood counts and liver function

Monitoring & Tests

• Complete blood counts regularly

• Liver and kidney function tests

• Monitor for infections and other adverse effects

Precautions & Warnings

• Use only under physician supervision

• Not recommended during pregnancy or breastfeeding without guidance

• Caution in patients with liver or kidney impairment

• Avoid abrupt discontinuation without medical advice