Colozo 145 mcg Capsules contain Linaclotide, a guanylate cyclase-C (GC-C) agonist used for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C). It helps improve bowel movement frequency, stool consistency, and reduces abdominal pain by increasing intestinal fluid secretion and accelerating gut transit.

Uses / Indications

Colozo 145 mcg is indicated for:

• Chronic Idiopathic Constipation (CIC)

• Irritable Bowel Syndrome with Constipation (IBS-C) in adults

Mechanism of Action

Linaclotide works by activating guanylate cyclase-C receptors on the intestinal epithelium. This leads to:

• Increased cyclic GMP (cGMP) levels

• Enhanced secretion of chloride and bicarbonate into the intestinal lumen

• Increased intestinal fluid and faster bowel movement

• Reduced visceral pain signaling

Dosage & Administration

• Recommended Dose: 145 mcg once daily

• Should be taken on an empty stomach, at least 30 minutes before the first meal of the day

• Capsule should be swallowed whole with water

⚠️ Dosage should be taken strictly as prescribed by a physician.

Side Effects

Common side effects include:

• Diarrhea

• Abdominal pain

• Flatulence

• Abdominal distension

Less common but serious:

• Severe diarrhea leading to dehydration

Precautions & Warnings

• Not recommended for patients below 18 years

• Contraindicated in known or suspected mechanical gastrointestinal obstruction

• Use caution in patients with severe diarrhea

• Discontinue if severe diarrhea occurs

Drug Interactions

• No major systemic drug interactions reported due to minimal absorption

• Inform doctor about all ongoing medications

Storage Instructions

• Store below 25°C

• Keep away from moisture and heat

• Keep out of reach of children

Key Highlights

• Effective treatment for IBS-C and chronic constipation

• Improves bowel regularity and abdominal discomfort

• Once-daily oral dosing

• Minimal systemic absorption

• Trusted brand from Dr. Reddy’s Laboratories